A team of researchers from the University of Illinois at Urbana-Champaign, making use of the gene-editing tools have recently developed a new way to influence on how the gene is regulated and expressed and how to eliminate a mutated gene sequence. In addition to this, the researchers have also adopted a new and innovative CRISPR technique which will cause a cell’s internal machinery to further skip over a small portion of the gene while transcribing it into the template for the building of protein.
The researchers further believe that by targeting the specific genes, they will be able to treat several genetic diseases that are caused by the mutation in the genome, such as Huntington’s disease, Duchenne’s muscular dystrophy, and some other types of cancer.
CRISPR technique generally turn the genes off by breaking their DNA at the very start of the targeted gene in order to induce mutations when the DNA binds them back together. Although, this can may a time causes the DNA to break into places that are outside of the intended target, which reattaches to several other chromosomes. This new technique is likely to alter a single point in the targeted DNA sequence more than breaking the complete DNA strands.
Furthermore, with the problems with the traditional method of gene editing by breaking the DNA, they are making notable efforts to find out new ways for the optimization of tools in order to accomplish the gene modifications. This is expected to be a good technique as they will be able to regulate the gene without the breaking of the genomic DNA.